Prazosin

(pra-zoe-sin)
Category: Alpha Adrenergic Blocker
Other Names for this Medication: Minipress®
Common Dosage Forms: Veterinary: None. Human: 1 mg, 2 mg, & 5 mg capsules. May need to be made (compounded) into lower strength capsules or an oral liquid for use in small animals.

This information sheet does not contain all available information for this medication. It is to help answer commonly asked questions and help you give the medication safely and

effectively to your animal. If you have other questions or need more information about this medication, contact your veterinarian or pharmacist.

Key Information

X Commonly used to decrease urinary tract spasms that may occur with inflammation.

X Give with food.
X Most common side effect is lethargy (tiredness/lack of

energy).

X May cause rapid heartbeat, hyperactivity, or higher body temperature. Contact your veterinarian immediately if any of these occur.

How is this medication useful?

In dogs and cats, prazosin may be prescribed for relaxing the urinary tract to allow passage of urine or bladder stones. Prazosin may also be prescribed in dogs to treat high blood pressure or heart failure.

The FDA (U.S. Food & Drug Administration) has approved this drug for use in humans, but it is not officially approved for use in ani- mals. The FDA allows veterinarians to prescribe products contain- ing this drug in different species or for other conditions in certain situations. You and your veterinarian can discuss why this drug is the most appropriate choice.

What should I tell my veterinarian to see if this medication can be safely given?

Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions.
XXOther drugs can interact with prazosin, so be sure to tell your

veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your animal, including the amount and time you give each.

XXTell your veterinarian if your dog has tested positive for a genetic mutation (ABCB1-1∆, also called MDR1).

XXTell your veterinarian about any conditions or diseases your pet may have now or has had in the past.

XXIf your animal has been treated for the same disease or condition in the past, tell your veterinarian how well the treatment worked.

XXIf your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug.

XXTell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your pet has developed in the past.

When should this medication not be used or be used very carefull?

No drug is 100% safe in all patients, but your veterinarian will discuss with you any specific concerns about using this drug in your animal.

This drug SHOULD NOT be used in patients:XXThat are allergic to it.
This drug should be used WITH CAUTION in:

XXDog breeds that may have a genetic mutation (ABCB1-1∆also called MDR1) until they are tested for this mutation. This mutation is most commonly found in “white feet” breeds, including Collies, Australian Shepherds, Shetland sheepdogs (Shelties), long-haired Whippets, etc. Dogs with this mutation may be overly sensitive and have reactions to the drug.

XXAnimals with kidney problems.XXAnimals with low blood pressure.

If your pet has any of these conditions or signs, talk to your veteri- narian about the potential risks versus benefits.

What are the side effects of this medication?

Common, but not serious side effects include:

XXLethargy (tiredness, lack of energy).

XXWeakness, dizziness.

XXGastrointestinal effects (eg, vomiting, lack of an appetite, diarrhea, constipation) are possible but not common.

You don’t have to be overly concerned if you see any of these unless they are severe, worsen, or continue to be a problem. Contact your veterinarian if this happens.

Side effects that may be serious or indicate a serious problem:

XXRapid heartbeat, hyperactivity or agitation (eg, nervous, upset, unable to relax), or increased body temperature.

If you see any of these, contact your veterinarian immediately.

If my pet gets too much of this medication (an overdose), what should I do?

One-time overdoses of prazosin may cause rapid heartbeat, hy- peractivity, fever or fainting. If you witness or suspect an overdose, contact your veterinarian or an animal poison control center for fur- ther advice. Animal poison control centers that are open 24 hours

a day include: Pet Poison HELPLINE (855-764-7661) and ASPCA Animal Poison Control Center (888-426-4435); a consultation fee is charged for these services.

©2017 PharmaVet, Inc. ALL RIGHTS RESERVED. Plumb’s® Veterinary Medication Guides have not been reviewed by FDA Center for Veterinary Medicine.

How should this medication be given?

For this medication to work, give it exactly as your veterinarian has prescribed. It’s a good idea to always check the prescription label to be sure you are giving the drug correctly.
XXGive this medication with food.

XXIf you have difficulty getting your animal to take the medicine, contact your veterinarian or pharmacist for tips to help dosing and reducing the stress of medication time.

XXThis medication can be given for various lengths of time. Be sure you understand how long your veterinarian wants you
to continue giving this medication. Prescription refills may be necessary before the therapy will be complete. Before stopping this medication, talk to your veterinarian, as there may be important reasons to continue its use.

What should I do if I miss giving a dose of this medication?

If you miss a dose, give it when you remember, but if it is close to the time for the next dose, skip the dose you missed and give it at the next schedule time. After that, return to the regular dosing schedule. Do not double-up or give extra doses.

How should I store this medication?

XXStore this medication in the original prescription bottle or an approved dosage reminder (ie, pill minder) container at room temperature; protect from moisture.

XXIf your veterinarian or pharmacist has made (compounded) a special formulation for your animal, follow the storage

recommendations and expiration date for the product. Keep away from children and other animals.

Can handling this medication be hazardous to me, my family, or other pets?

There are no specific precautions required when handling this med- ication unless you are allergic to it. Wash your hands after handling any medication.

How should I dispose of this medication if I don’t use it all?

XXDo not flush this medication down the toilet or wash it down the sink. If a community drug “take-back” program is available, use this option. If there is no take-back program, mix the drug with coffee grounds or cat litter (to make it undesirable to children and animals and unrecognizable to people who might go through your trash), place the mixture in a sealable plastic bag to keep it from leaking out, and throw the bag out with the regular trash.

XXDo not save left over medication for future use or give it to others to use.

What other information is important for this medication?

XXUse of this drug may not be allowed in certain animal competitions. Check rules and regulations before entering your animal in a competition while this medication is being administered.

If you have any other questions or concerns about this medica- tion, contact your veterinarian or pharmacist.

©2017 PharmaVet, Inc. ALL RIGHTS RESERVED. Plumb’s® Veterinary Medication Guides have not been reviewed by FDA Center for Veterinary Medicine.