Oclacitinib

(ok-la-sit-ti-nib)
Category: Anti-Itch & Anti-Inflammatory Agent
Other Names for this Medication: Apoquel®
Common Dosage Forms: Veterinary: 3.6 mg, 5.4 mg, & 16 mg tablets. Human: None.

This information sheet does not contain all available information for this medication. It is to help answer commonly asked questions and help you give the medication safely and effectively to your pet. If you have other questions or need more information, contact your veterinarian or pharmacist.

Key Information

XXBecause oclacitinib is a new medication, be sure to report any unexpected side effects to your veterinarian.

XXOclacitinib works quickly. Many dogs show improvement within the first few days of treatment.

XXThe most commonly reported side effects are vomiting, diarrhea, lack of appetite, increased thirst, and lethargy.

XXSerious side effects, including increased risk of infections and skin disorders, are possible.

XXThis medication is usually given twice a day for the first 2 weeks then decreased to once a day.

XXWash hands immediately after handling tablets.

How is this medication useful?

The FDA (U.S. Food & Drug Administration) has approved this drug for use in dogs that are at least 1 year of age for treating itch asso- ciated with allergic dermatitis and for controlling signs caused by atopic dermatitis. The FDA allows veterinarians to prescribe and use products containing this drug in different species or for other con- ditions in certain situations. You and your veterinarian can discuss why this drug is the most appropriate choice.

What should I tell my veterinarian to see if this medication can be safely given to my pet?

Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions.

XXOther drugs may interact with this medication, so be sure to tell your veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your pet, including the amount and time you give each.

XXTell your veterinarian about any conditions or diseases your pet may have now or has had in the past.

XXIf your animal has been treated for the same disease or condition in the past, tell your veterinarian about the treatment and how well it did or did not work.

XXIf your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug.

XXTell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your pet has developed in the past.

When should this medication not be used or be used very care- fully?

No drug is 100% safe in all patients, but your veterinarian will discuss with you any specific concerns about using this drug in your animal.

This drug SHOULD NOT be used in patients:XXThat are allergic to it.
XXWith serious infections.
XXThat are less than 12 months old.

XXThat are used for breeding or are pregnant or lactating. This drug should be used WITH CAUTION in patients:

XXWith ongoing infections.
If your pet has any of these conditions, talk to your veterinarian

about the potential risks versus benefits.

What are the side effects of this medication?

Due to its recent approval and limited clinical use, oclacitinib’s adverse effect profile is not fully known.

Side effects commonly reported that usually are not serious include:

XXVomiting, diarrhea, lack of appetite.

XXIncreased thirst.

XXLow energy level, tiredness.

If any of these signs are severe, worsen, or continue to be a prob- lem, contact your veterinarian.

Side effects that may be serious or indicate a serious problem:

XXIncreased possibility of infections. Watch for signs of infection including poor appetite, low energy level, high fever.

XXAny new growths seen on your pet.
XXSkin disorders, such as a rash or oozing sores.
If you see any of these signs, contact your veterinarian immediately.

If my animal gets too much of this medication (an overdose), what should I do?

If you witness or suspect an overdose, contact your veterinarian or an animal poison control center for further advice. Animal poison control centers open 24 hours a day include: Pet Poison HELPLINE(855-764-7661) and ASPCA Animal Poison Control Center (888- 426-4435); a consultation fee may be charged for these services.

How should this medication be given?

For this medication to work properly, give it exactly as your veteri- narian has prescribed. Check the prescription label to be sure you are giving the drug correctly.

XXThe drug may be given either with food or on an empty stomach. If your animal vomits or acts sick after receiving the drug on an empty stomach, try giving the next dose with food or a small treat. If vomiting continues, contact your veterinarian.

©2017 PharmaVet, Inc. ALL RIGHTS RESERVED. Plumb’s® Veterinary Medication Guides have not been reviewed by FDA Center for Veterinary Medicine.

XXCompounded liquid forms of this medication must be measured carefully. Your veterinarian or pharmacist can help by providing special measuring spoons or syringes.

XXIf you have difficulty getting your pet to take the medicine, contact your veterinarian or pharmacist for tips to help with dosing and reduce the stress of medication time for both you and your pet.

XXThis medication can be given for various lengths of time. Be sure you understand how long your veterinarian wants you to continue giving this medication. Prescription refills may be necessary before the therapy will be complete. If you want to stop giving this medication, talk to your veterinarian, as there may be important reasons to continue giving it.

What should I do if I miss giving my animal a dose of this medi- cation?

If you miss a dose, give it when you remember, but if it is close enough to the time for the next dose, skip the dose you missed and and give it at the next scheduled time. After that, return to the regu- lar dosing schedule. Do not double-up or give extra doses.

How should I store this medication?

XXStore this medication in the original prescription bottle or an approved dosage reminder container (ie, pill minder) at room temperature and protected from light.

XXIf your veterinarian or pharmacist has prepared (compounded) a special formulation for your animal, follow the storage recommendations and expiration date for the product.

XXKeep away from children and other animals.
Can handling this medication be hazardous to me, my family, or

other pets?

Pregnant women and people who are allergic to this drug should be very careful not to accidentally take it. Pregnant women should wear disposable gloves when giving doses or handling the drug and avoid inhaling any dust from split or crushed tablets. Skin or eyes exposed to powder or liquids containing the drug should immedi- ately be washed or rinsed off thoroughly. In the case of accidental eye contact, flush immediately with water or saline for at least 15 minutes and then seek medical attention. This drug may cause inflammation of the eyes (ie, conjunctivitis) if it comes into contact with the eye.

How should I dispose of this medication if I don’t use it all?

XXDo not flush this medication down the toilet or wash it down the sink. If a community drug “take-back” program is available, use this option. If there is no take-back program, mix the drug with coffee grounds or cat litter (to make it undesirable to children and animals and unrecognizable to people who might go through your trash), place the mixture in a sealable plastic bag to keep it from leaking out, and throw the bag out with the regular trash.

XXDo not save leftover medication for future use or give it to others to use.

What other information is important for this medication?

XXUse of this drug may not be allowed in certain animal competitions. Check rules and regulations before entering your animal in a competition while this medication is being administered.

If you have any other questions or concerns about this medica- tion, contact your veterinarian or pharmacist.

©2017 PharmaVet, Inc. ALL RIGHTS RESERVED. Plumb’s® Veterinary Medication Guides have not been reviewed by FDA Center for Veterinary Medicine.